The specialized, refined, differentiated, and innovative(SRDI)strategic orientation is that of enterprises with Chinese characteristics. The SRDI development is a strategic path for small and mediumsized enterprises (SMEs) to achieve sustained highquality development, but few studies have explored how SRDI development contributes to the growth of SMEs. Based on the theory of firm endogenous growth mechanism, this paper explores the procedure mechanisms and key situations of the SRDI strategic orientation empowering the growth of SMEs. The empirical results reveal that the SRDI strategic orientation can effectively promote the growth of SMEs, and its internal mechanism is that the SRDI strategic orientation empowers SMEs by enhancing their market power. However, there are specific boundary conditions for SRDI strategic orientation to play a role, among which the impact of the decoupling and the intensity of market competition will weaken the promoting effect of SRDI strategic orientation on the market power of SMEs. This paper provides theoretical insights and empirical references to promote the SRDI growth of SMEs.