Substantialism and phenomenologism are the main clues that runs through the development of western philosophy. From ancient Greece on, pursuing knowledge and truth has been the motif of western philosophy. Inevitably, this epistemologism will run to substantialism, which is the metaphysical foundation of the former. As the central thinking mode, substantialism is to divide the world into two parts, the major idea of which is after the root of things-substance- and substantial knowledge. It is Kant who turned the direction and led western philosophy into the road of phenomenologism that replaces substantial thinking with phenomenological ones. From the perspective of phenomenologism, knowledge is not to pursue the essence and substance of the world, but to reach the universality and objectivity of phenomena, which is transcendence over substantialism. In modern humanism philosophy, phenomenologism develops rapidly, with being against the dichotomy of subject and object and the essentialism of traditional philosophy as its central theme, and that's the main feature of the transition of modern philosophy.